
With its vast gallery of tragedies, if there’s anything the doctors of Grey’s Anatomy need, it’s therapy. Across 20 seasons, the hospital’s staff has gone through shootings, fires, car accidents, and plane crashes, just to name a few, and while they have a strong support system, and mostly get by with the help of their friends, the truth is that some situations require professional help. This is why, during the fourth season of the show, Amy Madigan’s Dr. Katharine Wyatt treated Ellen Pompeo’s Meredith Grey — and other doctors — to be able to overcome their fears and trauma.
Flashing forward to 2025, when you see Madigan bring to life Aunt Gladys’ demented character in Zach Cregger‘s Weapons, you will surely be floored. The vastly different portrayals of Aunt Gladys and Dr. Wyatt are a testament to Madigan’s range. Even though her last appearance was more than 15 years ago, Madigan left an unforgettable mark on Grey’s Anatomy.
Dr. Wyatt and Meredith Initially Clash on ‘Grey’s Anatomy’

Season 4 of Grey’s Anatomy takes place after several key moments in Meredith’s life. First, there was the Season 2 episode where she risks her life by holding an explosive inside a patient’s body, followed by the Season 3 ferry boat accident in which she almost drowned. Then, during the Season 3 finale, she breaks up with Derek due to their differing future aspirations. So, upon meeting Dr. Wyatt in “Where the Wild Things Are,” Meredith is in a dark place, lamenting Derek’s new relationship with Nurse Rose (Lauren Stamile), and hanging on by a thread through her new medical trial.
Dr. Wyatt is neither a soothing nor calming presence for Meredith. She isn’t there to be her friend. She’s there to help her develop the tools she needs to get out of her rut following her streak of adverse events. The aura of sternness and coldness that surrounds Dr. Wyatt lets her be confrontational with Meredith. After seeing that she won’t talk about her real feelings, Dr. Wyatt resorts to pushing and taunting her into a process of introspection.
Amy Madigan’s Dr. Wyatt Is a Key Character in Meredith Grey’s Evolution

Following the tragic death of one of Meredith’s patients, an exasperated Dr. Wyatt scolds her about using therapy to see the bright side of crappy events. On the contrary, she makes Meredith understand, explaining how she has to acknowledge her aches and pains to be able to process and truly overcome them. Dr. Wyatt draws a parallel between Meredith and her patient, exposing how his lonely death is what will eventually happen to her if she doesn’t accept her heart’s desire. Their clashing goes all the way to Dr. Wyatt implying she is a coward, with Meredith’s anger fueling further introspection.
Meredith takes a step in the right direction when she realizes how her past – and her ancestry – has marked her present-day decisions. It’s through these sessions that Meredith opens up for the first time about witnessing her mother’s suicide attempt at a young age. Together they conclude Ellis (Kate Burton) didn’t really want to die. Instead, in a twisted way, she was trying to get Richard (James Pickens Jr.) back. In the same vein, Meredith has had an utter disregard for her own life, as a subconscious way to get back with Derek (Patrick Dempsey).
But perhaps the most important realization that Dr. Wyatt helps Meredith with is how she’s been misinterpreting her mother’s words her whole life. When Ellis commands Meredith to “be extraordinary,” she didn’t mean she had to be an excellent surgeon. She was actually talking about Meredith doing what she herself never could: cultivate love and personal relationships. Ellis knew how she had screwed up this aspect of her life, wanting Meredith to avoid her mistakes, and live a fuller life. Getting to this point isn’t easy, but it’s a redefining moment in Meredith’s journey, helping her break free of the chains of the past.
‘Grey’s Anatomy’s Amy Madigan Left a Lasting Impact

Dr. Wyatt and Meredith’s interactions throughout Season 4 are mostly caps to episodes in the beginning and ending montages, with some moments sprinkled in between. But, even when they’re brief, they’re the highlights of a season that was affected by the 2009 WGA strike. Madigan excels as the unapologetic and unflinching Dr. Wyatt. Their quirky interactions, in which Meredith “fires her” but Wyatt insists she’s just quitting, are harsh but some of the realest things that have happened on Grey’s Anatomy. Thus, she never gives in to Meredith’s whims and, by remaining steadfast, gets her to develop the emotional tools she needs.
By the beginning of Season 5, we get to see Dr. Wyatt again. But it’s a bittersweet appearance, as it’s just for Meredith to say goodbye to her. Dr. Wyatt is adamant about Meredith’s process not being over yet, but that’s the last time we see them together. The scarce further appearances of Madigan’s character shift to her treating Owen (Kevin McKidd) after his PTSD triggers an attack on Cristina (Sandra Oh) during his sleep. Dr. Wyatt’s effectiveness is also seen in Owen’s therapy, as this starts to pave the way for him to be able to talk to Cristina about his time in Iraq, even if their love proved to be a match made in hell.
Meredith showed increased signs of improvement following her sessions with Dr. Wyatt. Three seasons after that, she had already dealt with these deep-rooted issues and found it in herself to start forming a family with Derek. Madigan is the second-best recurring guest star on Grey’s Anatomy following Constance Zimmer’s Alana Cahill, and Dr. Wyatt will remain a highlight of her career.