Grey’s Anatomy is set to release another exciting season with a vibrant cast. Grey’s Anatomy season 21 will feature several popular returning characters, like Meredith Grey and Miranda Bailey, who have appeared since the medical drama’s very first season in 2005. However, the new installment will also feature characters that have not been seen in a long time.
Grey’s Anatomy season 21 is set to feature reappearances by both Kali Rocha and Jesse Williams, who were once series regulars but have since left the show. The season will also address the Grey’s Anatomy season 20 finale that ended in mass firings and dramatic love triangles. The new and returning characters in season 21 are sure to be a part of Grey’s Anatomy‘s strongest cast yet.
| Grey’s Anatomy Season 21 Cast | |
| Actor | Character |
| Ellen Pompeo | Dr. Meredith Grey |
| Chandra Wilson | Dr. Miranda Bailey |
| James Pickens Jr. | Dr. Richard Webber |
| Kevin McKidd | Dr. Owen Hunt |
| Caterina Scorsone | Dr. Amelia Shepherd |
| Camila Luddington | Dr. Jo Wilson |
| Jason George | Dr. Ben Warren |
| Kim Raver | Dr. Teddy Altman |
| Jake Borelli | Dr. Levi Schmitt |
| Chris Carmack | Dr. Atticus Lincoln |
| Anthony Hill | Dr. Winston Ndugu |
| Alexis Floyd | Dr. Simone Griffith |
| Harry Shum Jr. | Dr. Benson Kwan |
| Adelaide Kane | Dr. Jules Millin |
| Midori Francis | Dr. Mika Yasuda |
| Niko Terho | Dr. Lucas Adams |
Ellen Pompeo as Dr. Meredith Grey
Date Of Birth: November 10, 1969
- Active Since: 1995
Actor: Ellen Pompeo was born in Massachusetts, and had her first screen appearance on Law & Order. She guest-starred on several shows, including Friends and Strong Medicine, until she broke big in Moonlight Mile in 2002. Her appearance in Moonlight Mile led to her being cast as Meredith Grey in Grey’s Anatomy.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Bertie Knox | Moonlight Mile |
| Karen Page | Daredevil |
| Dr. Meredith Grey | Grey’s Anatomy |
Character: Pompeo has played the lead in Grey’s Anatomy since the show’s premiere in 2005. Her notable character relationships include her friendship with Dr. Christina Yang and her relationship with Dr. Derek Shepherd. Meredith is a highly intelligent and complex character who sees the world in nuances.
Chandra Wilson as Dr. Miranda Bailey
Date Of Birth: August 27, 1969
- Active Since: 1989
Actor: Chandra Wilson was born in Texas and started her career on stage in off-broad performances. Her first television appearances include minor roles on The Cosby Show and Law & Order. She also appeared in the movie Philadelphia, but despite her significant praise, her breakout role was as Dr. Miranda Bailey in Grey’s Anatomy in 2005.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Chandra | Philadelphia |
| Athena | Lone Star |
| Dr. Miranda Bailey | Grey’s Anatomy |
Character: Bailey is a selfless and loyal character on Grey’s Anatomy and often puts others’ needs before her own. She is a major part of the hospital, and it is nearly impossible to imagine how Grey Sloan Memorial would run without her. Wilson’s Bailey has also appeared in several Grey’s Anatomy spinoffs.
James Pickens Jr. as Dr. Richard Webber
Date Of Birth: October 26, 1954
- Active Since: 1981
Actor: James Pickens Jr. was born in Ohio, and he had his first breakout role in the soap opera Another World. Pickens also guest-starred on several shows, including The X-Files and JAG. Pickens has a wide portfolio of acting credits, but he is best known for his role as Dr. Webber.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Zack Edwards and Hank | Another World |
| Henry Thomas | Beverly Hills, 90210 |
| Det. Hudson | Seinfeld |
| Commander Wallace Burke | JAG |
| Alvin Kersh | The X-Files |
| Dr. Richard Webber | Grey’s Anatomy |
Character: Richard is the attending general surgeon at Grey Sloan Memorial Hospital. He routinely acts as a mentor to several characters. His most notable relationship in season 21 is his relationship with Catherine Fox, as he is her husband and the Chief Medical Officer of the Catherine Fox Foundation.
Kevin McKidd as Dr. Owen Hunt
Date Of Birth: August 9, 1973
- Active Since: 1991
Actor: Kevin McKidd was born in Moray, Scotland, and he had his first major acting role in Trainspotting. McKidd has portrayed both serious and lighthearted characters. His notable roles include his voice acting in Brave and his portrayal of Andrew Bloom in It Ends With Us. The actor joined the ensemble cast in Grey’s Anatomy in season 5.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Tommy | Trainspotting |
| Count Vronsky | Anna Karenina |
| Lord MacGuffin | Brave |
| Andrew Bloom | It Ends With Us |
| Dr. Owen Hunt | Grey’s Anatomy |
Character: Owen is an excellent doctor who struggles with personal relationships. His most notable relationships include his broken marriage with Christina Yang and his divorce from Teddy Altman. He is assertive and stubborn, which helps his patients but wreaks havoc on his love life.
Caterina Scorsone as Dr. Amelia Shepherd
Date Of Birth: October 16, 1981
- Active Since: 1989
Actor: Caterina Scorsone was born in Toronto, Canada, and had her first television debut in the children’s program, Mr. Dressup. Her breakout role was in 1-800-Missing, where she played the lead. Scorsone has also appeared in several movies, including Crash and The November Man.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Celia | The November Man |
| Melissa | Edge Of Darkness |
| Jess Mastriani | 1-800-Missing |
| Dr. Amelia Shepherd | Grey’s Anatomy |
Character: Amelia was first introduced to Grey’s Anatomy through its spinoff, Private Practice. Amelia is the late Dr. Derek Shepherd’s sister. As a result, she is closely connected to Meredith Grey and their surrounding mutual friends.
Camila Luddington as Dr. Jo Wilson
Date Of Birth: December 15, 1983
- Active Since: 2007
Actor: Camilla Luddington was born in Berkshire, England, and had her first major role as Kate in William & Kate: The Movie. Luddington broke big when she was cast as the voice of Lara Croft in the Tomb Raider video game. She joined the Grey’s Anatomy cast in season 9.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Lara Croft | Tomb Raider |
| Cecilia | The Healer |
| Dr. Jo Wilson | Grey’s Anatomy |
Character: Jo is a bubbly and friendly doctor who gets along well with the other characters in Grey’s Anatomy. Her most notable relationships include her past relationship with Alex Karev and her current relationship with Link, which has been complicated by the news that Jo is pregnant, as revealed in the Grey’s Anatomy season 20 finale.
Jason George as Dr. Ben Warren
Date Of Birth: February 9, 1972
- Active Since: 1997
Actor: Jason George was born in Virginia, and he broke big in Sunset Beach as Michael Bourne. George has appeared in a variety of shows and movies and his most notable appearances include his roles in Mistresses and Station 19.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Michael Bourne | Sunset Beach |
| Keith Bennett | Eli Stone |
| Dominic Taylor | Mistresses |
| Dr. Ben Warren | Grey’s Anatomy and Station 19 |
Character: Ben has played both a doctor and a firefighter in Grey’s Anatomy. He is best known for being Miranda Bailey’s loving husband. Ben was first introduced to Grey’s Anatomy as a supporting character in season 6 and later became a series regular.
Kim Raver as Dr. Teddy Altman
Date Of Birth: March 15, 1969
- Active Since: 1975
Actor: Kim Raver was born in New York City, and had her first major role as a child on Sesame Street. She later appeared in several Broadway performances, and she had her first major movie role in City Hall. Raver is best known for her role as Audrey Raines in 24.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Kim Zambrano | Third Watch |
| Erica Daley | Night at the Museum |
| Renee | Prisoner |
| Dr. Andrea Frost | Designated Survivor |
| Audrey Raines | 24 |
| Dr. Teddy Altman | Grey’s Anatomy |
Character: Teddy is a complicated character on Grey’s Anatomy. She is a highly skilled doctor, but she also struggles in her personal relationships, similar to her ex-husband Owen Hunt. Teddy joined the cast in season 6.
Jake Borelli as Dr. Levi Schmitt
Date Of Birth: May 13, 1991
- Active Since: 2007
Actor: Jake Borelli was born in Ohio, and he had his first breakout role in The Thundermans. Borelli has appeared in several movies, including #Realityhigh and The Thing About Harry. He is best known for his role as Dr. Levi Schmitt in Grey’s Anatomy.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Sam Basilli | The Thing About Harry |
| Wolfgang | The Thundermans |
| Dr. Levi Schmitt | Grey’s Anatomy |
Character: Levi is a surgical resident at Grey Sloan who started his career as an intern back in season 17. He is kind and gentle but is often clumsy, which shows up in his work and personal life. His most notable relationship is his romantic relationship with Nico Kim.
Chris Carmack as Dr. Atticus “Link” Lincoln
Date Of Birth: December 22, 1980
- Active Since: 2000
Actor: Chris Carmack was born in Maryland and broke big in the teen drama The O.C. Carmack has appeared in several teen dramas and one of his most notable appearances was in The Butterfly Effect franchise. He joined the Grey’s Anatomy cast as Link in season 15.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Luke Ward | The O.C. |
| Jason Masters | Lovewrecked |
| Sam Reide | The Butterfly Effect |
| Dennis | Shark Night |
| Will Lexington | Nashville |
| Link | Grey’s Anatomy |
Character: Link is a sweet doctor who always wants the best for his patients. He has a complicated relationship with Amelia Shepherd and is currently in a relationship with Jo Wilson. He is also very supportive and an attentive father.
Anthony Hill as Dr. Winston Ndugu
Date Of Birth: November 11, 1987
- Active Since: 2011
Actor: Anthony Hill was born in Missouri and has appeared as a guest star in several television shows. Hill’s first major role was in Colony. He is best known for playing Winston Ndugu in Grey’s Anatomy.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Dr. Winston Ndugu | Grey’s Anatomy |
| Black Mac | It’s Always Sunny In Philadelphia |
| Check Point Redhat | Colony |
Character: Winston is a caring and brilliant surgeon. He is best known for his relationship with Maggie Pierce, which ended in season 20. Grey’s Anatomy season 20 also revealed a potential love triangle between him, Amelia, and Beltran.
Alexis Floyd as Dr. Simone Griffith
Date Of Birth: December 22, 1993
- Active Since: 2017
Actor: Alexis Floyd was born in Ohio, and she broke big with her portrayal of Neff in Inventing Anna. She has also guest-starred in several shows, including The Good Fight. Floyd joined the Grey’s Anatomy cast in season 19.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Deandra Minton | The Good Fight |
| Neff | Inventing Anna |
| Dr. Simone Griffith | Grey’s Anatomy |
Character: Simone is a surgical intern at Grey Sloan Memorial. She is funny, incredibly smart, and has a difficult family history. She has a fiancé but also has an ongoing flirty relationship with Lucas.
Harry Shum Jr. as Dr. Benson Kwan
Date Of Birth: April 28, 1982
- Active Since: 2000
Actor: Harry Shum Jr. was born in Costa Rica, and he had his first major role in Glee but also appeared in the Step Up franchise. Shum is best known for his appearances in Shadowhunters and Crazy Rich Asians. He joined the Grey’s Anatomy cast in season 19.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Mike Chang and Joe Hart | Glee |
| Charlie Wu | Crazy Rich Asians |
| Magnus Bane and Valentine Morgenstern | Shadowhunters |
| Owen Lin | Love Hard |
| Chad | Everything Everywhere All At Once |
| Dr. Benson Kwan | Grey’s Anatomy |
Character: A smart and competitive doctor, Benson has a tendency to be impatient and is slow to develop trust in others. Currently, he’s involved in a casual relationship with Jules Millin.
Adelaide Kane as Dr. Jules Millin
Date Of Birth: August 9, 1990
- Active Since: 2005
Actor: Adelaide Kane was born in Western Australia, and she broke big through her role as Lolly Allen in Neighbours. She is best known for her roles on television. In 2022, she joined the Grey’s Anatomy cast.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Lolly Allen | Neighbours |
| Mary Stuart | Reign |
| Zoey Sandin | The Purge |
| Ivy Belfrey and Drizella | Once Upon A Time |
| Dr. Jules Millin | Grey’s Anatomy |
Character: Jules was one of several interns to join Grey’s Anatomy in season 19. She comes from a difficult family life and can be strict at times. She has had romantic relationships with Link and Benson.
Midori Francis as Dr. Mika Yasuda
Date Of Birth: April 16, 1994
- Active Since: 2014
Actor: Midori Iwama was born in New Jersey, and she began her career in theater performances. She broke big in Ocean’s 8. Iwama joined the Grey’s Anatomy cast in season 19.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Dr. Mika Yasuda | Grey’s Anatomy |
| Alicia | The Sex Lives Of College Girls |
| Lily | Dash & Lily |
| April | Ocean’s 8 |
Character: Mika is highly adaptable and uses her family history to her advantage. She is also a very resourceful character. Mika’s most notable relationship has been her relationship with Jules.
Niko Terho as Dr. Lucas Adams
Date Of Birth: February 3, 1996
- Active Since: 2019
Actor: Niko Terho was born in Barbados, and he broke big in The Thing About Harry. Terho has appeared in a few things since he began his career, but his most notable role has been playing Lucas in Grey’s Anatomy. He joined the cast in season 19.
Notable Movies & TV Shows:
| Role | Movie/TV Show |
| Dr. Lucas Adams | Grey’s Anatomy |
| Jeff | Sno Babies |
| Harry Turpin | The Thing About Harry |
Character: Lucas is Meredith’s nephew through marriage. He is the black sheep of the Shepherd family and faces several struggles while being an intern at Grey Sloan. He lives with Mika and Simone.
Grey’s Anatomy Supporting Cast & Characters
The Large Ensemble Cast Also Features Several Supporting Characters
Debbie Allen: Allen plays the vibrant and conniving Catherine Fox. Known for being the Grey’s Anatomy season 20 villain, Catherine does what she wants. She is also known for her relationship with Richard.
Jesse Williams: Williams is coming back to Grey’s Anatomy to portray Jackson Avery again. He is Catherine’s son and is known for his difficult personal relationships. Williams originally left the show in season 19.
Kali Rocha: Rocha is also returning to Grey’s Anatomy as her character Sydney Herron. Sydney was a minor character in seasons 2-4. Her return will stir up old memories of past Grey’s Anatomy seasons.